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Inferring the Rate-Length Law of Protein Folding

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<p>Guest post from Dr. Gregory Bowman, University of California, Berkeley</p>

<p>One objective of the Folding@home project is to provide

insight into general protein folding mechanisms that hold across a variety of

systems. For example, how much slower,

on average, do longer proteins take to fold than shorter ones? To address questions like this, Lane and

Pande recently developed a theoretical framework for testing different models

of the scaling of protein folding times with chain length against experimental

observations (line <a href="http://arxiv.org/abs/1301.4302">here</a>). One of their major

conclusions is that there is insufficient data to distinguish between many of

the possible models. All is not lost

though. The framework they developed

also allows them to point out the types of measurements that need to be made to

conclusively determine which of the models that have been proposed is

best. In the future, it will be exciting

to begin both computational and experimental studies of these systems. </p>

 

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