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Le calme avant la tempĂȘte ? đ
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Je suis venu rendre une petite visite, histoire de voir comment ça se passait par ici. Si tu as un peu de potion de reste, jâen prendrais bien une pinte !
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Salut Jaques, tu es venus te perdre par ici ? J'ai bu le plus gros du stock, il ne faudrait pas laisser partir Ă perte, tu sais bien comment que c'est, mais il reste toujours quelque futs au frais
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FlĂ»te, jâarrive trop tard, ou bien il reste quelques biĂšres ? đ
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Salut la compagnie ! Comment ça va ?
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JVallois joined the community
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alo145 joined the community
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Nouvelle mouture des stats avec design remis Ă neuf grĂące aux membres de la Zebteam accessible sur : https://fah.chezmks.fr/ Les stats de la PcPerf team sont ici : https://fah.chezmks.fr/PcPerf.html
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The best diagram of the #SARSCoV2 virus sucker, with its protein components, that I've seen Link to come later from accompanying @NEJM essaypic.twitter.com/7P2r9QjrL6 Afficher sur Twitter
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Global organization @FoldingatHome is researching #COVID19 proteins that could help with designing therapeutics. This AI for Health grantee harnesses the collected power of millions of volunteers through Azure and GitHub. #MSBuildpic.twitter.com/f6c2XHqOg7 Afficher sur Twitter
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Excited to share that we are studying SARS-CoV-2 Spike protein dynamics and its perturbations (if any) upon mutation. Thanks @bradyajohnston for a great illustration of our work! @FatihiSaman @Surabhi_CSB @deep_anshi @NidhiJatana A thread to explain our recent findingspic.twitter.com/Lgg0YLVIRG Afficher sur Twitter
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One of the @drGregBowman labâs go-to analyses for analyzing F@h trajectories is called Exposons! In this edition of #FAHPastSuccesses Porter and Moeder et al combined F@h data with experimental measurements to demonstrate the existence of a new pocket in beta-lactamase!pic.twitter.com/gRqs6hWcUi Afficher sur Twitter
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Salut pat1ent00 J'avais prĂ©parĂ© quelques biĂšres pensant voir quelques retours d'anciens plieurs, mais faute de volontaires j'ai Ă©tĂ© obligĂ© de tout boire Quand tu voudras installer Folding, ne soit pas Ă©tonnĂ© si tu as un message de Windows, le certificat de la toute derniĂšre version est pĂ©rimĂ©, si l'Ă©quipe de F@H se bouge le cul, ça devrait ĂȘtre rĂ©solu bientĂŽt, mais de toute maniĂšre ça ne gĂȘne pas pour l'installer
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topic revival Miaou à tous et TG de biÚre ( Je check si je peux faire tourner folding@home, malgré mes machines asthmatiques )
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Todayâs #FAHMeetTheProteins features the Nucleoprotein RNA binding domain! https://www.biorxiv.org/content/10.1101/2020.03.06.977876v1.full âŠpic.twitter.com/CMkgn7jUWk Afficher sur Twitter
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A lot of you have been eager for more work units, so we wanted to give you an overview of our process and a status update. Weâre working hard to get more work servers up and running in response to our rapid growth in users. Stay tuned!pic.twitter.com/860T3z0jVb Afficher sur Twitter
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We want to let you all know what proteins we are simulating, what they do, and what we hope to learn from these studies! Weâll call it #FAHMeetTheProteins Todayâs protein is nsp10 from SARS and SARS-CoV2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162180/ âŠpic.twitter.com/8xyM5rlEGK Afficher lâarticle complet
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The F@h team is working hard to generate as many new #COVID19 WUs as possible. In the meantime you may get a WU for another disease, and thatâs okay! We care very deeply about addressing our current global health threat, but we also care about preventing future ones. Afficher lâarticle complet
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Tiens, une tĂȘte connue Bah, on ne se refait pas
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DK-cahuĂšte changed their profile photo
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Bas les pattes !! Et reste Ă un mĂštre stp... (je sers â je serre)
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DK-cahuĂšte joined the community
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Envie d'aider la recherche contre le Coronavirus grĂące Ă votre ordinateur ? Rejoignez le projet Folding at Home simplement en installant un logiciel sur votre ordinateur. Plus de renseignement sur https://alliancefrancophone.org/dossiers/covid19 ⊠Afficher lâarticle complet
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Advanced controller: FenĂȘtre d'information et de paramĂ©trage de Folding at Home accessible en cliquant droit sur lâicĂŽne de F@H dans la zone de notification. Calcul distribuĂ©: Client: Partie du logiciel servant Ă effectuer les calculs, le logiciel F@H peut piloter parallĂšlement plusieurs clients, par exemple un client CPU et un client GPU. CPU: AbrĂ©viation pour le processeur principal de l'ordinateur, Central Processor Unit Deadline: GPU: AbrĂ©viation pour le processeur de la carte ou puce graphique Graphic processor unit F@H: AbrĂ©viation pour parler de Folding at Home Folding at Home ProtĂ©ines Stanford Vijay Pande Web controller WU: Work Unit, unitĂ© de calcul, chaque client, dĂšs qu'il est lancĂ©, tĂ©lĂ©charge une WU, en effectue le calcul, puis la renvoie aux serveurs de Stanford avant d'en tĂ©lĂ©charger une nouvelle.
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Depuis courant 2017, les stats des différents miniteams hébergés sur http://folding.fleucorp.net ne sont plus fonctionnelles. Pourquoi ? MystÚre, malheureusement depuis il semble impossible de reprendre contact avec leur créateur, JGP SOLDAT. En octobre 2017, Kana-chan, un membre de la mini team Zebulon a repris le script des stats que JGP SOLDAT avait mis à disposition des membres de l'AF et a réussi à les remettre en service. Vous pouvez retrouver ces stats sur https://www.folding.fr/stat/kana/folding/ Les stats de la mini team PcPerf se trouvent là .
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A venir
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Folding@home update on SARS-CoV-2 (10 Mar 2020) March 10, 2020 by John Chodera This is an update on Folding@homeâs efforts to assist researchers around the world taking up the global fight against COVID-19. After initial quality control and limited testing phases, Folding@home team has released an initial wave of projects simulating potentially druggable protein targets from SARS-CoV-2 (the virus that causes COVID-19) and the related SARS-CoV virus (for which more structural data is available) into full production on Folding@home. Many thanks to the large number of Folding@home donors who have assisted us thus far by running in beta or advanced modes. This initial wave of projects focuses on better understanding how these coronaviruses interact with the human ACE2 receptor required for viral entry into human host cells, and how researchers might be able to interfere with them through the design of new therapeutic antibodies or small molecules that might disrupt their interaction. In the coming days, we hope to take advantage of some of the new structural biology and biochemical data that is being rapidly released by researchers around the world who are working to understand these viruses and strategies for defeating them. This work has been largely disseminated by preprint servers such as bioRxiv and chemRxiv, which aim to make research rapidly available to both other researchers and the public for other scientists to broadly evaluate and immediately start building on. We have also forged several new collaborations with other laboratories where we hope Folding@home will provide valuable support in COVID-19 research efforts. While we will rapidly release the simulation datasets for others to use or analyze, we aim to look for alternative conformations and hidden pockets within the most promising drug targets, which can only be seen in simulation and not in static X-ray structures. We hope that these structuresâonce validated by emerging compound screening dataâcould help direct the virtual screening campaigns or the targeting of new pockets for which atomistic structures were not yet available. Below, we provide short descriptions of the projects. Note that all input files are being made available on GitHub here for other researchers to take advantage of: https://github.com/foldingathome/coronavirus This repository will evolve over the coming days as we add more projects and documentation. We will start posting datasets with structures on publicly available servers as soon as we have useful data to report. All projects are using the new GPU-accelerated Core22 based on the open source OpenMM biomolecular simulation engine. SARS-CoV-2 RBD domain in complex with human ACE2 receptor (PDBID: 6vsb, 6acg) [10.1126/science.abb2507, 10.1371/journal.ppat.1007236] 11741: Coronavirus SARS-CoV-2 (COVID-19 causing virus) receptor binding domain in complex with human receptor ACE2. atoms: 165550, credit: 15396 11746: Coronavirus SARS-CoV-2 (COVID-19 causing virus) receptor binding domain in complex with human receptor ACE2 (alternative structure to 11741). atoms: 182699, credit: 16615 SARS-CoV-2 main protease in complex with an inhibitor N3 (PDBID: 6lu7) [Not yet published] 11742: Coronavirus SARS-CoV-2 (COVID-19 causing virus) protease in complex with an inhibitor. atoms: 62227, credit: 9405 11743: Coronavirus SARS-CoV-2 (COVID-19 causing virus) protease â potential drug target. atoms: 62180, credit: 9405 SARS-CoV-2 RBD domain in complex with human neutralizing S230 antibody Fab fragment (PDBIDs: 6nb7, 6nb8, 2ghv) [ 10.1016/j.cell.2018.12.028 (for both 6nb7 and 6nb8), 10.1074/jbc.M603275200] 11744: Coronavirus SARS-CoV (SARS causing virus) receptor binding domain trapped by a SARS-CoV S230 antibody. atoms: 109578, credit: 7608 11745: Coronavirus SARS-CoV (SARS causing virus) receptor binding domain mutated to the SARS-CoV-2 (COVID-19 causing virus) trapped by a SARS-CoV S230 antibody. atoms: 110370, credit: 7685 To contact us to discuss collaborations or data, please email us at foldingathome@choderalab.org Special thanks to TBCP graduate student Rafal Wiewiora and CBM graduate student Ivy Zhang for their work in modeling these structures from existing experimental data and preparing these projects, and to all the Folding@home donors who help make this work possible! ~ The Chodera lab SARS-CoV-2 team and Folding@home Consortium ~
